SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		4 / 8 GLY A 251
LYS A 250
GLY A 253
ASP A 222
 None
 0.82A 1aegA-2kxhA:
undetectable		 1aegA-2kxhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		5 / 11 ILE A 183
GLY A 154
HIS A 152
LEU A 123
GLY A 117
 None
 1.43A 2fn1A-2kxhA:
undetectable		 2fn1A-2kxhA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2kxh PEPTIDE OF FAR
UPSTREAM
ELEMENT-BINDING
PROTEIN 1
POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		5 / 12 LEU B  35
LEU A 220
LEU A 275
MET A 270
PHE B  31
 None
 1.20A 3g1uC-2kxhB:
undetectable		 3g1uC-2kxhB:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2kxh PEPTIDE OF FAR
UPSTREAM
ELEMENT-BINDING
PROTEIN 1
POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		5 / 12 LEU B  35
LEU A 220
LEU A 275
MET A 270
PHE B  31
 None
 1.22A 3glqA-2kxhB:
undetectable		 3glqA-2kxhB:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2kxh PEPTIDE OF FAR
UPSTREAM
ELEMENT-BINDING
PROTEIN 1
POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		5 / 12 LEU B  35
LEU A 220
LEU A 275
MET A 270
PHE B  31
 None
 1.19A 3n58D-2kxhB:
undetectable		 3n58D-2kxhB:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		4 / 8 SER A 175
VAL A 176
VAL A 282
GLY A 283
 None
 1.03A 4mk4A-2kxhA:
undetectable		 4mk4A-2kxhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		5 / 12 LEU A 220
ASP A 224
LEU A 240
GLY A 253
PHE A 273
 None
 1.26A 4pfjA-2kxhA:
undetectable		 4pfjA-2kxhA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens) 		5 / 8 VAL A 185
ILE A 183
VAL A 158
PHE A 157
VAL A 114
 None
 1.32A 5l94A-2kxhA:
undetectable		 5l94A-2kxhA:
19.01