SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens) 		4 / 8 THR B 129
LEU B 184
VAL B 147
VAL B 164
 None
 0.89A 1iwiA-2kxnB:
undetectable		 1iwiA-2kxnB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens) 		3 / 3 ASP B 192
ASN B 180
SER B 194
 None
None
G  A   3 ( 2.3A)
 0.98A 3lslA-2kxnB:
undetectable
3lslD-2kxnB:
undetectable		 3lslA-2kxnB:
19.29
3lslD-2kxnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens) 		3 / 3 SER B 194
ASP B 192
ASN B 180
 G  A   3 ( 2.3A)
None
None
 0.98A 3lslA-2kxnB:
undetectable
3lslD-2kxnB:
undetectable		 3lslA-2kxnB:
19.29
3lslD-2kxnB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens) 		3 / 3 TYR B 128
ARG B 187
SER B 126
 None
A  A   1 ( 4.4A)
None
 1.20A 4lf7I-2kxnB:
undetectable
4lf7J-2kxnB:
2.1		 4lf7I-2kxnB:
21.28
4lf7J-2kxnB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens) 		3 / 3 TYR B 128
ARG B 187
SER B 126
 None
A  A   1 ( 4.4A)
None
 1.20A 4lf8I-2kxnB:
undetectable
4lf8J-2kxnB:
2.1		 4lf8I-2kxnB:
21.28
4lf8J-2kxnB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens) 		4 / 6 PHE B 161
SER B 158
LEU B 127
LEU B 125
 G  A   3 ( 3.4A)
None
None
None
 1.11A 5dzke-2kxnB:
undetectable
5dzks-2kxnB:
undetectable		 5dzke-2kxnB:
20.19
5dzks-2kxnB:
4.08