SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
(Gallus
gallus) 		4 / 4 HIS A  52
ALA A  51
PHE A  54
GLY A  49
 None
 1.31A 1mjoA-2kxpA:
undetectable		 1mjoA-2kxpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 5 ASP B 338
LEU B 325
ALA B 309
LEU B 306
 None
 1.15A 1nh8A-2kxpB:
undetectable		 1nh8A-2kxpB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.08A 1qzfA-2kxpB:
undetectable		 1qzfA-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.08A 1qzfB-2kxpB:
undetectable		 1qzfB-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.07A 1qzfC-2kxpB:
undetectable		 1qzfC-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.08A 1qzfD-2kxpB:
undetectable		 1qzfD-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.08A 1qzfE-2kxpB:
undetectable		 1qzfE-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 ASP A 270
ILE A 274
ILE A 269
GLY B 514
ILE B 513
 None
 0.92A 2o4nA-2kxpA:
undetectable		 2o4nA-2kxpA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.15A 2oipC-2kxpB:
undetectable		 2oipC-2kxpB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		3 / 3 SER B 390
HIS B 509
ASP B 505
 None
 0.78A 2oxtA-2kxpB:
undetectable		 2oxtA-2kxpB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 ALA B 400
GLY B 430
TYR B 420
ALA B 429
LEU B 424
 None
 1.11A 2plwA-2kxpB:
undetectable		 2plwA-2kxpB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 GLU B 521
ARG A 259
HIS B 452
ILE B 432
VAL B 517
 None
 1.42A 2qeoA-2kxpB:
undetectable		 2qeoA-2kxpB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 5 GLY B 491
GLY B 490
PHE A 255
PHE B 533
 None
 1.01A 2qr2A-2kxpB:
undetectable
2qr2B-2kxpB:
undetectable		 2qr2A-2kxpB:
22.91
2qr2B-2kxpB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 6 LEU B 310
VAL B 343
LEU A  39
ASP B 327
 None
 0.83A 3cs9D-2kxpB:
undetectable		 3cs9D-2kxpB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
(Gallus
gallus) 		3 / 3 ASN A  30
MET A  59
PHE A  54
 None
 0.95A 3g4lD-2kxpA:
undetectable		 3g4lD-2kxpA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.12A 3hj3C-2kxpB:
undetectable		 3hj3C-2kxpB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gB-2kxpB:
undetectable		 3j6gB-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gD-2kxpB:
undetectable		 3j6gD-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gF-2kxpB:
undetectable		 3j6gF-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gH-2kxpB:
undetectable		 3j6gH-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gJ-2kxpB:
undetectable		 3j6gJ-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gL-2kxpB:
undetectable		 3j6gL-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gN-2kxpB:
undetectable		 3j6gN-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gP-2kxpB:
undetectable		 3j6gP-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 10 VAL B 473
ASP B 449
PHE B 533
THR A 253
LEU B 477
 None
 1.28A 3j6gR-2kxpB:
undetectable		 3j6gR-2kxpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 8 TYR B 407
ILE B 432
VAL B 517
ILE B 510
 None
 0.87A 3p4wC-2kxpB:
undetectable		 3p4wC-2kxpB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
(Gallus
gallus) 		5 / 12 PHE A  96
TYR A 144
ILE A  76
MET A  59
VAL A  74
 None
 1.42A 3sp6A-2kxpA:
0.0		 3sp6A-2kxpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
(Gallus
gallus) 		4 / 5 ILE A 154
SER A 147
LYS A 146
GLY A 145
 None
 1.17A 3tkdA-2kxpA:
undetectable		 3tkdA-2kxpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2kxp MYOTROPHIN
(Mus
musculus) 		3 / 3 LYS C 637
PRO C 638
LEU C 639
 None
 0.63A 3tpxE-2kxpC:
undetectable		 3tpxE-2kxpC:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		6 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
VAL B 431
THR B 472
 None
 1.09A 4eckB-2kxpB:
undetectable		 4eckB-2kxpB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 7 TYR A 198
ILE B 531
LEU B 489
GLY B 490
 None
 0.89A 4iqqA-2kxpA:
undetectable		 4iqqA-2kxpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 8 TYR A 198
ILE B 531
LEU B 489
GLY B 490
 None
 0.80A 4iqqD-2kxpA:
undetectable		 4iqqD-2kxpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.11A 4ky8B-2kxpB:
undetectable		 4ky8B-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 6 ASP B 405
ASN B 401
ALA B 403
ASP B 409
 None
 1.13A 4mdaA-2kxpB:
undetectable		 4mdaA-2kxpB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
(Gallus
gallus) 		4 / 7 TYR A 136
GLU A 233
GLU A 236
TYR A 239
 None
 1.12A 4mi4A-2kxpA:
undetectable
4mi4C-2kxpA:
undetectable		 4mi4A-2kxpA:
22.46
4mi4C-2kxpA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.07A 4q0dA-2kxpB:
undetectable		 4q0dA-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.07A 4q0dB-2kxpB:
undetectable		 4q0dB-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 12 VAL B 453
LEU B 347
ASP B 344
SER B 341
THR B 472
 None
 1.07A 4q0dE-2kxpB:
undetectable		 4q0dE-2kxpB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 11 ASP A 270
ILE A 274
ILE A 269
GLY B 514
ILE B 513
 None
 0.94A 4q1xA-2kxpA:
undetectable		 4q1xA-2kxpA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		5 / 8 ILE B 549
LEU A 192
VAL B 540
LEU B 543
ILE A 194
 None
 1.38A 4r38D-2kxpB:
1.4		 4r38D-2kxpB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
MYOTROPHIN
(Gallus
gallus;
Mus
musculus) 		3 / 3 ARG C 636
THR A 253
ASP A 252
 None
 0.93A 5g5gA-2kxpC:
undetectable
5g5gB-2kxpC:
undetectable		 5g5gA-2kxpC:
20.35
5g5gB-2kxpC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus) 		4 / 8 TYR A 198
ILE B 531
LEU B 489
GLY B 490
 None
 0.85A 5nooD-2kxpA:
undetectable		 5nooD-2kxpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
MYOTROPHIN
(Gallus
gallus;
Mus
musculus) 		3 / 3 LYS C 611
LYS B 442
SER B 441
 None
 1.40A 5odiA-2kxpC:
undetectable		 5odiA-2kxpC:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus;
Gallus
gallus) 		4 / 7 GLN A 205
VAL A 196
PRO B 317
ILE A 194
 None
 0.98A 6cduF-2kxpA:
undetectable
6cduG-2kxpA:
undetectable		 6cduF-2kxpA:
23.30
6cduG-2kxpA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
(Gallus
gallus;
Gallus
gallus) 		4 / 8 GLN A 205
VAL A 196
PRO B 317
ILE A 194
 None
 0.99A 6cduG-2kxpA:
undetectable
6cduH-2kxpA:
undetectable		 6cduG-2kxpA:
23.30
6cduH-2kxpA:
23.30