SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2kxr TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		4 / 8 THR A   1
LEU A  52
GLU A  61
LYS A  44
 None
 1.20A 1mxgA-2kxrA:
undetectable		 1mxgA-2kxrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2kxr TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 9 LEU A  83
SER A  25
ILE A  41
ALA A  69
THR A  62
 None
 1.29A 3mdtA-2kxrA:
undetectable		 3mdtA-2kxrA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxr TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 ALA A  70
LEU A  75
ILE A  28
PRO A  29
THR A  62
 None
 1.00A 3nrrA-2kxrA:
undetectable		 3nrrA-2kxrA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kxr TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 ALA A  70
LEU A  75
ILE A  28
PRO A  29
THR A  62
 None
 0.98A 3nrrB-2kxrA:
undetectable		 3nrrB-2kxrA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 2kxr TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens) 		5 / 12 PHE A  10
GLY A  23
PHE A  77
VAL A  81
ILE A  28
 None
 1.17A 5tuiB-2kxrA:
undetectable		 5tuiB-2kxrA:
13.41