SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2kxs TIGHT JUNCTION
PROTEIN ZO-1,
LINKER, PEPTIDE OF
MYOCARDIUM-ENRICHED
ZO-ASSOCIATED
PROTEIN
(Homo
sapiens;
synthetic
construct) 		4 / 8 LEU A  77
THR A  36
LEU A  78
VAL A  38
 None
 0.96A 1sn5C-2kxsA:
undetectable		 1sn5C-2kxsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2kxs TIGHT JUNCTION
PROTEIN ZO-1,
LINKER, PEPTIDE OF
MYOCARDIUM-ENRICHED
ZO-ASSOCIATED
PROTEIN
(Homo
sapiens;
synthetic
construct) 		4 / 7 ILE A  23
LEU A  31
ASN A  25
ILE A  47
 None
 0.87A 1yc2E-2kxsA:
undetectable		 1yc2E-2kxsA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2kxs TIGHT JUNCTION
PROTEIN ZO-1,
LINKER, PEPTIDE OF
MYOCARDIUM-ENRICHED
ZO-ASSOCIATED
PROTEIN
(Homo
sapiens;
synthetic
construct) 		4 / 7 PRO A  43
GLY A  45
ALA A  46
ASP A 130
 None
 0.75A 3ur0B-2kxsA:
undetectable		 3ur0B-2kxsA:
14.63