SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N49_B_RITB301_2 (PROTEASE)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 11	GLY A 53 ALA A 52 VAL A 87 GLY A 18 ILE A 89	None	0.94A	1n49B-2kylA: undetectable	1n49B-2kylA: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9L_A_CAMA1419_0 (CYTOCHROME P450)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 12	ILE A 80 THR A 91 GLY A 53 VAL A 40 ILE A 60	None	1.01A	4c9lA-2kylA: undetectable	4c9lA-2kylA: 15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9L_B_CAMB1419_0 (CYTOCHROME P450)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 12	ILE A 80 THR A 91 GLY A 53 VAL A 40 ILE A 60	None	1.05A	4c9lB-2kylA: undetectable	4c9lB-2kylA: 15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9O_A_CAMA423_0 (CYTOCHROME P450)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 12	ILE A 80 THR A 91 GLY A 53 VAL A 40 ILE A 60	None	1.01A	4c9oA-2kylA: undetectable	4c9oA-2kylA: 15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9O_B_CAMB423_0 (CYTOCHROME P450)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 12	ILE A 80 THR A 91 GLY A 53 VAL A 40 ILE A 60	None	1.02A	4c9oB-2kylA: undetectable	4c9oB-2kylA: 15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UBS_A_DIFA502_1 (PENTALENIC ACID SYNTHASE)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 9	LEU A 94 LEU A 54 THR A 91 LEU A 59 ILE A 60	None	1.32A	4ubsA-2kylA: undetectable	4ubsA-2kylA: 11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZJI_A_PQNA844_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	2kyl	MICROTUBULE-ASSOCIAT ED SERINE/THREONINE-PRO TEIN KINASE 2 (Homo sapiens)	5 / 10	PHE A 19 GLY A 47 ILE A 9 ALA A 52 LEU A 54	None	1.20A	5zjiA-2kylA: undetectable 5zjiJ-2kylA: undetectable	5zjiA-2kylA: 18.10 5zjiJ-2kylA: 23.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N49_B_RITB301_2","PROTEASE","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"GLY A  53;ALA A  52;VAL A  87;GLY A  18;ILE A  89","None","0.94A","1n49B-2kylA:undetectable","1n49B-2kylA:20.39"],["4C9L_A_CAMA1419_0","CYTOCHROME P450","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"ILE A  80;THR A  91;GLY A  53;VAL A  40;ILE A  60","None","1.01A","4c9lA-2kylA:undetectable","4c9lA-2kylA:15.27"],["4C9L_B_CAMB1419_0","CYTOCHROME P450","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"ILE A  80;THR A  91;GLY A  53;VAL A  40;ILE A  60","None","1.05A","4c9lB-2kylA:undetectable","4c9lB-2kylA:15.27"],["4C9O_A_CAMA423_0","CYTOCHROME P450","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"ILE A  80;THR A  91;GLY A  53;VAL A  40;ILE A  60","None","1.01A","4c9oA-2kylA:undetectable","4c9oA-2kylA:15.27"],["4C9O_B_CAMB423_0","CYTOCHROME P450","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"ILE A  80;THR A  91;GLY A  53;VAL A  40;ILE A  60","None","1.02A","4c9oB-2kylA:undetectable","4c9oB-2kylA:15.27"],["4UBS_A_DIFA502_1","PENTALENIC ACID SYNTHASE","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"LEU A  94;LEU A  54;THR A  91;LEU A  59;ILE A  60","None","1.32A","4ubsA-2kylA:undetectable","4ubsA-2kylA:11.57"],["5ZJI_A_PQNA844_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","2kyl","MICROTUBULE-ASSOCIATED SERINE\/THREONINE-PROTEIN KINASE 2","Homo sapiens",5,"PHE A  19;GLY A  47;ILE A   9;ALA A  52;LEU A  54","None","1.20A","5zjiA-2kylA:undetectable;5zjiJ-2kylA:undetectable","5zjiA-2kylA:18.10;5zjiJ-2kylA:23.91"]]