SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		4 / 8 VAL A  65
ALA A   7
PHE A  75
GLU A  82
 None
 0.87A 1dmiA-2kyrA:
undetectable
1dmiB-2kyrA:
undetectable		 1dmiA-2kyrA:
13.86
1dmiB-2kyrA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		5 / 12 THR A  59
ILE A  96
ILE A  95
GLU A  26
ASN A  48
 None
 1.09A 1jtxA-2kyrA:
undetectable		 1jtxA-2kyrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		5 / 11 ALA A  58
SER A  64
ILE A  83
ILE A  99
TYR A  34
 None
 1.27A 2blaA-2kyrA:
undetectable		 2blaA-2kyrA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		5 / 10 TYR A  81
ILE A  95
TYR A  34
ILE A  96
GLU A 100
 None
 1.31A 3u6tA-2kyrA:
undetectable		 3u6tA-2kyrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		3 / 3 GLY A  45
GLU A  39
THR A  40
 None
 0.52A 4kouA-2kyrA:
undetectable		 4kouA-2kyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		5 / 10 GLU A 100
ALA A  28
ILE A  95
ALA A   7
ILE A  62
 None
 1.06A 4lbgA-2kyrA:
4.7		 4lbgA-2kyrA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1
(Escherichia
coli) 		5 / 12 ALA A  21
ALA A  22
LEU A  85
ALA A  88
ILE A  46
 None
 0.97A 6a5yD-2kyrA:
undetectable		 6a5yD-2kyrA:
25.25