SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_A_CUA1599_0 (NITROUS OXIDE REDUCTASE)	2kyu	HISTONE-LYSINE N-METHYLTRANSFERASE MLL (Homo sapiens)	3 / 3	CYH A 11 CYH A 38 HIS A 35	ZN A 81 (-2.3A) ZN A 81 (-2.4A) ZN A 81 (-3.1A)	0.68A	2iwkA-2kyuA: undetectable	2iwkA-2kyuA: 7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IWK_B_CUB1599_0 (NITROUS OXIDE REDUCTASE)	2kyu	HISTONE-LYSINE N-METHYLTRANSFERASE MLL (Homo sapiens)	3 / 3	CYH A 11 CYH A 38 HIS A 35	ZN A 81 (-2.3A) ZN A 81 (-2.4A) ZN A 81 (-3.1A)	0.65A	2iwkB-2kyuA: undetectable	2iwkB-2kyuA: 7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_B_CUB1022_0 (CYTOCHROME C OXIDASE SUBUNIT 2)	2kyu	HISTONE-LYSINE N-METHYLTRANSFERASE MLL (Homo sapiens)	3 / 3	CYH A 11 CYH A 38 HIS A 35	ZN A 81 (-2.3A) ZN A 81 (-2.4A) ZN A 81 (-3.1A)	0.63A	3dtuB-2kyuA: undetectable	3dtuB-2kyuA: 13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_D_CUD3_0 (CYTOCHROME C OXIDASE SUBUNIT 2)	2kyu	HISTONE-LYSINE N-METHYLTRANSFERASE MLL (Homo sapiens)	3 / 3	CYH A 11 CYH A 38 HIS A 35	ZN A 81 (-2.3A) ZN A 81 (-2.4A) ZN A 81 (-3.1A)	0.63A	3dtuD-2kyuA: undetectable	3dtuD-2kyuA: 13.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2IWK_A_CUA1599_0","NITROUS OXIDE REDUCTASE","2kyu","HISTONE-LYSINE N-METHYLTRANSFERASE MLL","Homo sapiens",3,"CYH A  11;CYH A  38;HIS A  35"," ZN A  81 (-2.3A); ZN A  81 (-2.4A); ZN A  81 (-3.1A)","0.68A","2iwkA-2kyuA:undetectable","2iwkA-2kyuA:7.72"],["2IWK_B_CUB1599_0","NITROUS OXIDE REDUCTASE","2kyu","HISTONE-LYSINE N-METHYLTRANSFERASE MLL","Homo sapiens",3,"CYH A  11;CYH A  38;HIS A  35"," ZN A  81 (-2.3A); ZN A  81 (-2.4A); ZN A  81 (-3.1A)","0.65A","2iwkB-2kyuA:undetectable","2iwkB-2kyuA:7.72"],["3DTU_B_CUB1022_0","CYTOCHROME C OXIDASE SUBUNIT 2","2kyu","HISTONE-LYSINE N-METHYLTRANSFERASE MLL","Homo sapiens",3,"CYH A  11;CYH A  38;HIS A  35"," ZN A  81 (-2.3A); ZN A  81 (-2.4A); ZN A  81 (-3.1A)","0.63A","3dtuB-2kyuA:undetectable","3dtuB-2kyuA:13.39"],["3DTU_D_CUD3_0","CYTOCHROME C OXIDASE SUBUNIT 2","2kyu","HISTONE-LYSINE N-METHYLTRANSFERASE MLL","Homo sapiens",3,"CYH A  11;CYH A  38;HIS A  35"," ZN A  81 (-2.3A); ZN A  81 (-2.4A); ZN A  81 (-3.1A)","0.63A","3dtuD-2kyuA:undetectable","3dtuD-2kyuA:13.39"]]