SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
5 / 12 GLU A  32
VAL A   7
LEU A  54
LEU A  51
VAL A  28
None
1.14A 1sn5B-2kyzA:
undetectable
1sn5D-2kyzA:
undetectable
1sn5B-2kyzA:
16.15
1sn5D-2kyzA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
5 / 12 LEU A  54
LEU A  51
VAL A  28
GLU A  32
VAL A   7
None
1.13A 1sn5B-2kyzA:
undetectable
1sn5D-2kyzA:
undetectable
1sn5B-2kyzA:
16.15
1sn5D-2kyzA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
4 / 5 CYH A  15
TYR A   6
PRO A  60
SER A  11
None
1.07A 1ymxA-2kyzA:
0.4
1ymxA-2kyzA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
5 / 12 LEU A  26
LEU A   5
LEU A  51
ALA A  22
THR A  44
None
1.11A 3dfrA-2kyzA:
undetectable
3dfrA-2kyzA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
4 / 8 VAL A  61
VAL A  40
TYR A   3
TYR A  64
None
0.81A 4puoC-2kyzA:
5.7
4puoC-2kyzA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
4 / 8 VAL A  61
VAL A  40
TYR A   3
TYR A  64
None
0.78A 4pwdA-2kyzA:
6.0
4pwdA-2kyzA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
4 / 8 VAL A  61
VAL A  40
TYR A   3
TYR A  64
None
0.71A 4q0bA-2kyzA:
6.1
4q0bA-2kyzA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima)
4 / 8 LEU A  47
VAL A  40
VAL A  28
LEU A   5
None
0.85A 6czmD-2kyzA:
5.5
6czmF-2kyzA:
5.4
6czmD-2kyzA:
12.17
6czmF-2kyzA:
12.17