SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		4 / 8 SER A 261
ARG A 359
PHE A 346
ASN A 280
 None
 1.34A 1rs6A-2kzbA:
undetectable		 1rs6A-2kzbA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 277
GLN A 276
PHE A 278
LEU A 285
 None
 1.11A 1v55C-2kzbA:
undetectable
1v55J-2kzbA:
undetectable		 1v55C-2kzbA:
16.48
1v55J-2kzbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		5 / 11 ASN A 339
LEU A 277
PHE A 346
LEU A 262
TYR A 320
 None
 1.49A 1xpqC-2kzbA:
0.0		 1xpqC-2kzbA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		4 / 8 SER A 261
ARG A 359
PHE A 346
ASN A 280
 None
 1.36A 1zzqA-2kzbA:
undetectable		 1zzqA-2kzbA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 277
GLN A 276
PHE A 278
LEU A 285
 None
 1.12A 2einP-2kzbA:
undetectable
2einW-2kzbA:
undetectable		 2einP-2kzbA:
16.48
2einW-2kzbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 317
ASN A 279
ARG A 260
PHE A 278
 None
 1.18A 2fl5E-2kzbA:
undetectable
2fl5F-2kzbA:
3.7		 2fl5E-2kzbA:
17.59
2fl5F-2kzbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2kzb AUTOPHAGY-RELATED
PROTEIN 19
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 358
LEU A 262
LEU A 291
TYR A 320
MET A 307
 None
 1.14A 5jqbA-2kzbA:
undetectable
5jqbB-2kzbA:
undetectable		 5jqbA-2kzbA:
17.17
5jqbB-2kzbA:
20.41