SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		5 / 12 THR A  34
GLY A  35
ILE A  43
LEU A  64
LEU A  14
 None
 1.04A 1r30A-2kzrA:
undetectable		 1r30A-2kzrA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		5 / 12 THR A  34
GLY A  35
ILE A  43
LEU A  64
LEU A  14
 None
 1.04A 1r30B-2kzrA:
undetectable		 1r30B-2kzrA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		4 / 5 VAL A   3
LEU A  17
LEU A  61
ILE A  30
 None
 0.91A 4a9jA-2kzrA:
undetectable		 4a9jA-2kzrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		4 / 5 VAL A   3
LEU A  17
LEU A  61
ILE A  30
 None
 0.94A 4a9jB-2kzrA:
undetectable		 4a9jB-2kzrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		4 / 5 VAL A   3
LEU A  17
LEU A  61
ILE A  30
 None
 0.94A 4a9jC-2kzrA:
undetectable		 4a9jC-2kzrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		5 / 12 LEU A  14
ILE A  33
GLY A  28
ILE A  43
VAL A  74
 None
 0.97A 4nkxA-2kzrA:
undetectable		 4nkxA-2kzrA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		5 / 12 LEU A  14
ILE A  33
GLY A  28
ILE A  43
VAL A  74
 None
 1.05A 4nkxC-2kzrA:
undetectable		 4nkxC-2kzrA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		5 / 12 LEU A  14
ILE A  33
GLY A  28
ILE A  43
VAL A  74
 None
 1.05A 4nkxD-2kzrA:
undetectable		 4nkxD-2kzrA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		5 / 12 GLY A  62
ARG A  22
ILE A  59
ARG A  20
LEU A  17
 None
 1.04A 5fa8A-2kzrA:
undetectable		 5fa8A-2kzrA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2kzr UBIQUITIN
THIOESTERASE OTU1
(Mus
musculus) 		4 / 8 ARG A   4
ILE A  33
LEU A  17
GLY A  16
 None
 0.71A 5nooD-2kzrA:
undetectable		 5nooD-2kzrA:
14.61