SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2kzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 11 ILE A 172
ASP A 180
GLY A 179
PHE A 176
VAL A 184
 None
 1.39A 1axwB-2kztA:
undetectable		 1axwB-2kztA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		4 / 7 PHE A 240
ALA A 268
PHE A 264
SER A 220
 None
 1.29A 1lqtA-2kztA:
undetectable		 1lqtA-2kztA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ILE A 273
THR A 233
ASP A 235
SER A 239
LEU A 222
 None
 0.98A 1rjdA-2kztA:
undetectable		 1rjdA-2kztA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ILE A 273
THR A 233
ASP A 235
SER A 239
LEU A 222
 None
 0.99A 1rjdB-2kztA:
undetectable		 1rjdB-2kztA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ILE A 273
THR A 233
ASP A 235
SER A 239
LEU A 222
 None
 0.97A 1rjdC-2kztA:
undetectable		 1rjdC-2kztA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.11A 2oipA-2kztA:
undetectable		 2oipA-2kztA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.09A 2oipB-2kztA:
undetectable		 2oipB-2kztA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.13A 2oipC-2kztA:
undetectable		 2oipC-2kztA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.16A 2oipD-2kztA:
undetectable		 2oipD-2kztA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		4 / 7 TYR A 278
PRO A 201
LEU A 223
ALA A 268
 None
 0.86A 2vcvA-2kztA:
undetectable		 2vcvA-2kztA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 THR A 277
ASN A 276
VAL A 269
GLY A 270
ALA A 266
 None
 0.99A 2x2iA-2kztA:
undetectable		 2x2iA-2kztA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 THR A 277
ASN A 276
VAL A 269
GLY A 270
ALA A 266
 None
 0.99A 2x2iC-2kztA:
undetectable		 2x2iC-2kztA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.15A 3hj3A-2kztA:
undetectable		 3hj3A-2kztA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.15A 3hj3B-2kztA:
undetectable		 3hj3B-2kztA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 294
LEU A 243
PHE A 240
SER A 239
LEU A 223
 None
 1.13A 3hj3C-2kztA:
undetectable		 3hj3C-2kztA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens) 		5 / 9 LEU A 223
VAL A 261
LEU A 295
PHE A 240
VAL A 236
 None
 1.49A 3jwqA-2kztA:
undetectable		 3jwqA-2kztA:
20.80