SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A
(Homo
sapiens) 		4 / 7 PHE A  60
VAL A  90
ASP A  65
ILE A  66
 None
 0.94A 1p7rA-2l08A:
undetectable		 1p7rA-2l08A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A
(Homo
sapiens) 		4 / 7 TYR A  86
LEU A  46
ASP A  45
ALA A  44
 None
 1.04A 3rodD-2l08A:
undetectable		 3rodD-2l08A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A
(Homo
sapiens) 		5 / 12 LEU A  26
ALA A  88
PHE A  73
PHE A  69
LEU A  33
 None
 1.03A 4hytA-2l08A:
undetectable		 4hytA-2l08A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A
(Homo
sapiens) 		5 / 12 LEU A  26
ALA A  88
PHE A  73
PHE A  69
LEU A  33
 None
 1.03A 4hytC-2l08A:
undetectable		 4hytC-2l08A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A
(Homo
sapiens) 		5 / 9 ALA A  56
PHE A  42
GLU A  27
LEU A  17
ILE A  14
 None
 1.44A 5i73A-2l08A:
undetectable		 5i73A-2l08A:
10.53