SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1
(Homo
sapiens) 		3 / 3 CYH A  43
CYH A  69
HIS A  66
 ZN  A 143 (-2.4A)
ZN  A 143 (-2.4A)
ZN  A 143 (-3.1A)
 0.79A 2iwkA-2l0bA:
undetectable		 2iwkA-2l0bA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1
(Homo
sapiens) 		3 / 3 CYH A  43
CYH A  69
HIS A  66
 ZN  A 143 (-2.4A)
ZN  A 143 (-2.4A)
ZN  A 143 (-3.1A)
 0.78A 2iwkB-2l0bA:
undetectable		 2iwkB-2l0bA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1
(Homo
sapiens) 		3 / 3 CYH A  43
CYH A  69
HIS A  66
 ZN  A 143 (-2.4A)
ZN  A 143 (-2.4A)
ZN  A 143 (-3.1A)
 0.76A 3dtuB-2l0bA:
undetectable		 3dtuB-2l0bA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1
(Homo
sapiens) 		3 / 3 CYH A  43
CYH A  69
HIS A  66
 ZN  A 143 (-2.4A)
ZN  A 143 (-2.4A)
ZN  A 143 (-3.1A)
 0.75A 3dtuD-2l0bA:
undetectable		 3dtuD-2l0bA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1
(Homo
sapiens) 		3 / 3 PRO A  90
ASN A  14
HIS A  10
 None
 0.95A 4ma3H-2l0bA:
undetectable
4ma3L-2l0bA:
undetectable		 4ma3H-2l0bA:
14.81
4ma3L-2l0bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2l0b E3 UBIQUITIN-PROTEIN
LIGASE PRAJA-1
(Homo
sapiens) 		4 / 6 ALA A  56
VAL A  70
ASP A  54
TYR A  50
 None
 1.16A 5umd2-2l0bA:
undetectable
5umdF-2l0bA:
undetectable		 5umd2-2l0bA:
20.00
5umdF-2l0bA:
22.92