SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_B_BAXB1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	2l0t	SIGNAL TRANSDUCING ADAPTER MOLECULE 2 (Homo sapiens)	4 / 6	ILE B 104 VAL B 103 VAL B 20 ILE B 39	None	0.80A	1uwhB-2l0tB: undetectable	1uwhB-2l0tB: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_A_ACTA148_0 (UPF0066 PROTEIN AF_0241)	2l0t	SIGNAL TRANSDUCING ADAPTER MOLECULE 2 (Homo sapiens)	3 / 3	VAL B 20 GLU B 17 GLU B 21	None	0.72A	2nv4A-2l0tB: undetectable	2nv4A-2l0tB: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKW_B_DR7B100_2 (PROTEASE)	2l0t	SIGNAL TRANSDUCING ADAPTER MOLECULE 2 (Homo sapiens)	5 / 12	ARG B 60 GLY B 77 ALA B 78 ALA B 23 ILE B 36	None	0.99A	3ekwB-2l0tB: undetectable	3ekwB-2l0tB: 16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGH_C_FLPC701_1 (CYCLOOXYGENASE-2)	2l0t	SIGNAL TRANSDUCING ADAPTER MOLECULE 2 (Homo sapiens)	6 / 12	VAL B 91 LEU B 76 VAL B 43 GLY B 49 ALA B 50 LEU B 54	None	1.41A	3pghC-2l0tB: undetectable	3pghC-2l0tB: 14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJO_A_ERYA1101_0 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	2l0t	SIGNAL TRANSDUCING ADAPTER MOLECULE 2 (Homo sapiens)	5 / 12	ASN B 14 SER B 45 ALA B 50 GLU B 17 LEU B 75	None	1.48A	4zjoA-2l0tB: undetectable	4zjoA-2l0tB: 10.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UWH_B_BAXB1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","2l0t","SIGNAL TRANSDUCING ADAPTER MOLECULE 2","Homo sapiens",4,"ILE B 104;VAL B 103;VAL B  20;ILE B  39","None","0.80A","1uwhB-2l0tB:undetectable","1uwhB-2l0tB:22.22"],["2NV4_A_ACTA148_0","UPF0066 PROTEIN AF_0241","2l0t","SIGNAL TRANSDUCING ADAPTER MOLECULE 2","Homo sapiens",3,"VAL B  20;GLU B  17;GLU B  21","None","0.72A","2nv4A-2l0tB:undetectable","2nv4A-2l0tB:19.53"],["3EKW_B_DR7B100_2","PROTEASE","2l0t","SIGNAL TRANSDUCING ADAPTER MOLECULE 2","Homo sapiens",5,"ARG B  60;GLY B  77;ALA B  78;ALA B  23;ILE B  36","None","0.99A","3ekwB-2l0tB:undetectable","3ekwB-2l0tB:16.76"],["3PGH_C_FLPC701_1","CYCLOOXYGENASE-2","2l0t","SIGNAL TRANSDUCING ADAPTER MOLECULE 2","Homo sapiens",6,"VAL B  91;LEU B  76;VAL B  43;GLY B  49;ALA B  50;LEU B  54","None","1.41A","3pghC-2l0tB:undetectable","3pghC-2l0tB:14.69"],["4ZJO_A_ERYA1101_0","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","2l0t","SIGNAL TRANSDUCING ADAPTER MOLECULE 2","Homo sapiens",5,"ASN B  14;SER B  45;ALA B  50;GLU B  17;LEU B  75","None","1.48A","4zjoA-2l0tB:undetectable","4zjoA-2l0tB:10.45"]]