SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2l10 TALIN-1
(Mus
musculus) 		5 / 12 PHE A1281
ALA A1215
ILE A1308
ILE A1346
LEU A1316
 None
 1.08A 2bjfA-2l10A:
undetectable		 2bjfA-2l10A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2l10 TALIN-1
(Mus
musculus) 		5 / 12 PHE A1281
ALA A1215
ILE A1308
ILE A1346
LEU A1316
 None
 1.04A 2rlcA-2l10A:
undetectable		 2rlcA-2l10A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2l10 TALIN-1
(Mus
musculus) 		5 / 11 LEU A1249
ALA A1253
LEU A1256
ALA A1212
VAL A1216
 None
 1.25A 3e22B-2l10A:
undetectable		 3e22B-2l10A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2l10 TALIN-1
(Mus
musculus) 		5 / 11 LEU A1249
ALA A1253
LEU A1256
ALA A1212
VAL A1216
 None
 1.26A 3e22D-2l10A:
undetectable		 3e22D-2l10A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2l10 TALIN-1
(Mus
musculus) 		5 / 12 GLY A1217
ALA A1215
PHE A1278
PHE A1281
LEU A1249
 None
 1.21A 4hytC-2l10A:
3.0		 4hytC-2l10A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2l10 TALIN-1
(Mus
musculus) 		5 / 11 ALA A1245
LEU A1242
GLU A1287
LEU A1305
LEU A1349
 None
 1.00A 4wg0C-2l10A:
undetectable
4wg0D-2l10A:
undetectable
4wg0E-2l10A:
undetectable		 4wg0C-2l10A:
7.09
4wg0D-2l10A:
7.09
4wg0E-2l10A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2l10 TALIN-1
(Mus
musculus) 		4 / 6 VAL A1301
LEU A1305
CYH A1353
LEU A1242
 None
 1.18A 5hrqB-2l10A:
undetectable
5hrqI-2l10A:
undetectable
5hrqJ-2l10A:
undetectable		 5hrqB-2l10A:
15.70
5hrqI-2l10A:
7.74
5hrqJ-2l10A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2l10 TALIN-1
(Mus
musculus) 		4 / 4 GLN A1356
THR A1354
LEU A1305
LEU A1349
 None
 1.30A 5m5kB-2l10A:
undetectable		 5m5kB-2l10A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2l10 TALIN-1
(Mus
musculus) 		4 / 7 PHE A1274
ASP A1277
LEU A1249
SER A1309
 None
 1.06A 5uxcA-2l10A:
2.7		 5uxcA-2l10A:
21.40