SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2l1l EXPORTIN-1
(Homo
sapiens) 		3 / 3 VAL B 604
VAL B 602
TRP B 559
 None
 0.85A 1av2C-2l1lB:
undetectable
1av2D-2l1lB:
undetectable		 1av2C-2l1lB:
12.28
1av2D-2l1lB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2l1l CAMP-DEPENDENT
PROTEIN KINASE
INHIBITOR ALPHA
EXPORTIN-1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR B 620
GLU B 571
ASP A  18
 None
 0.78A 1nt2A-2l1lB:
undetectable		 1nt2A-2l1lB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2l1l EXPORTIN-1
(Homo
sapiens) 		3 / 3 VAL B 604
VAL B 602
TRP B 559
 None
 0.83A 1w5uC-2l1lB:
undetectable
1w5uD-2l1lB:
undetectable		 1w5uC-2l1lB:
12.28
1w5uD-2l1lB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2l1l EXPORTIN-1
(Homo
sapiens) 		3 / 3 VAL B 602
TRP B 559
VAL B 604
 None
 0.83A 2izqA-2l1lB:
undetectable
2izqB-2l1lB:
undetectable		 2izqA-2l1lB:
12.28
2izqB-2l1lB:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2l1l EXPORTIN-1
(Homo
sapiens) 		3 / 3 VAL B 604
VAL B 602
TRP B 559
 None
 0.90A 3l8lC-2l1lB:
undetectable
3l8lD-2l1lB:
undetectable		 3l8lC-2l1lB:
12.28
3l8lD-2l1lB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2l1l EXPORTIN-1
(Homo
sapiens) 		4 / 5 THR B 587
ILE B 591
LYS B 590
PHE B 570
 None
 1.45A 4ac9C-2l1lB:
undetectable		 4ac9C-2l1lB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2l1l CAMP-DEPENDENT
PROTEIN KINASE
INHIBITOR ALPHA
EXPORTIN-1
(Homo
sapiens) 		4 / 7 PHE B 572
ALA B 541
ILE B 521
LEU A  14
 None
 1.05A 4uymA-2l1lB:
undetectable		 4uymA-2l1lB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2l1l CAMP-DEPENDENT
PROTEIN KINASE
INHIBITOR ALPHA
EXPORTIN-1
(Homo
sapiens) 		4 / 7 PHE B 572
ALA B 541
ILE B 521
LEU A  14
 None
 1.09A 4uymB-2l1lB:
undetectable		 4uymB-2l1lB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2l1l EXPORTIN-1
(Homo
sapiens) 		5 / 12 GLU B 613
ILE B 521
GLY B 549
THR B 587
LEU B 569
 None
 1.21A 5esgA-2l1lB:
undetectable		 5esgA-2l1lB:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2l1l EXPORTIN-1
(Homo
sapiens) 		5 / 7 PHE B 588
ILE B 591
PHE B 554
LEU B 555
CYH B 595
 None
 1.43A 6b5vA-2l1lB:
undetectable
6b5vB-2l1lB:
2.7		 6b5vA-2l1lB:
18.11
6b5vB-2l1lB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2l1l EXPORTIN-1
(Homo
sapiens) 		5 / 7 PHE B 588
PHE B 554
LEU B 555
CYH B 595
ILE B 614
 None
 1.29A 6b5vA-2l1lB:
undetectable
6b5vB-2l1lB:
2.7		 6b5vA-2l1lB:
18.11
6b5vB-2l1lB:
18.11