SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 218
GLU A 322
ILE A 323
LEU A 247
ILE A 215
 None
 1.12A 1d1gB-2l26A:
undetectable		 1d1gB-2l26A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 153
PHE A 142
LEU A 133
ALA A 138
 None
 0.92A 1fiqC-2l26A:
undetectable		 1fiqC-2l26A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 322
ILE A 223
ASN A 216
ASP A 228
GLY A 226
 None
 1.25A 1hvyA-2l26A:
undetectable		 1hvyA-2l26A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 322
ILE A 223
ASN A 216
ASP A 228
GLY A 226
 None
 1.26A 1hvyB-2l26A:
undetectable		 1hvyB-2l26A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 322
ILE A 223
ASN A 216
ASP A 228
GLY A 226
 None
 1.30A 1hvyC-2l26A:
undetectable		 1hvyC-2l26A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 160
SER A 132
LEU A 153
LEU A  93
PHE A  97
 None
 1.15A 1mx1E-2l26A:
undetectable		 1mx1E-2l26A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 320
ILE A 223
ASN A 241
VAL A 281
TYR A 284
 None
 1.50A 2nyrB-2l26A:
undetectable		 2nyrB-2l26A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 12 SER A  87
THR A  90
VAL A  91
LEU A  93
ILE A  84
 None
 1.45A 2xrlA-2l26A:
undetectable		 2xrlA-2l26A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 164
ILE A 188
PHE A 135
PHE A 142
 None
 0.92A 3ko0K-2l26A:
undetectable
3ko0S-2l26A:
undetectable		 3ko0K-2l26A:
13.84
3ko0S-2l26A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 281
LEU A 285
VAL A 218
THR A 219
 None
 0.93A 4ma7A-2l26A:
undetectable		 4ma7A-2l26A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 300
ALA A 278
VAL A 324
ILE A 323
 None
 0.93A 4xe3B-2l26A:
undetectable		 4xe3B-2l26A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 324
GLU A 322
GLY A 259
LEU A 300
 None
 0.90A 5w3jB-2l26A:
undetectable		 5w3jB-2l26A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 153
PHE A 151
LEU A 106
ALA A 109
LEU A 113
 None
 1.26A 5y7pB-2l26A:
undetectable		 5y7pB-2l26A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 153
PHE A 151
LEU A 106
ALA A 109
LEU A 113
 None
 1.27A 5y7pD-2l26A:
undetectable		 5y7pD-2l26A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 153
PHE A 151
LEU A 106
ALA A 109
LEU A 113
 None
 1.26A 5y7pH-2l26A:
undetectable		 5y7pH-2l26A:
23.31