SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		4 / 8 TYR A 135
TYR A 131
SER A 103
SER A  52
 None
 1.19A 2vmyA-2l2bA:
undetectable
2vmyB-2l2bA:
undetectable		 2vmyA-2l2bA:
17.33
2vmyB-2l2bA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		4 / 6 MET A 157
ARG A 141
GLY A 145
TRP A 146
 None
 1.46A 3aqiA-2l2bA:
undetectable		 3aqiA-2l2bA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		5 / 9 TYR A  90
ILE A 171
ILE A 173
VAL A 100
ILE A 119
 None
 1.07A 3p4wA-2l2bA:
undetectable		 3p4wA-2l2bA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		5 / 8 TYR A  90
ILE A 171
ILE A 173
VAL A 100
ILE A 119
 None
 1.08A 3p4wC-2l2bA:
undetectable		 3p4wC-2l2bA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		5 / 9 GLY A   4
ALA A   3
GLY A  73
LEU A  17
VAL A  20
 None
 0.98A 3u7sB-2l2bA:
undetectable		 3u7sB-2l2bA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		3 / 3 ASN A 138
ASP A 143
GLY A 142
 None
 0.47A 5fctB-2l2bA:
undetectable		 5fctB-2l2bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		5 / 12 ILE A   7
VAL A  20
PHE A 102
VAL A 100
ILE A  35
 None
 0.98A 5mueA-2l2bA:
undetectable		 5mueA-2l2bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2l2b STICHOLYSIN-2
(Stichodactyla
helianthus) 		5 / 10 TYR A  90
ILE A 171
ILE A 173
VAL A 100
ILE A 119
 None
 1.24A 5mzrC-2l2bA:
undetectable		 5mzrC-2l2bA:
21.83