SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 5 LEU A 107
ARG A  96
TRP A  50
ILE A  41
 None
 1.49A 2cmlA-2l2fA:
undetectable		 2cmlA-2l2fA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 5 LEU A 107
ARG A  96
TRP A  50
ILE A  41
 None
 1.46A 2cmlB-2l2fA:
undetectable		 2cmlB-2l2fA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 5 LEU A 107
ARG A  96
TRP A  50
ILE A  41
 None
 1.43A 2cmlC-2l2fA:
undetectable		 2cmlC-2l2fA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 5 LEU A 107
ARG A  96
TRP A  50
ILE A  41
 None
 1.46A 2cmlD-2l2fA:
undetectable		 2cmlD-2l2fA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 6 ASP A 100
TYR A  40
PHE A   4
LEU A  19
 None
 1.22A 2w98A-2l2fA:
undetectable
2w98B-2l2fA:
undetectable		 2w98A-2l2fA:
15.67
2w98B-2l2fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 8 LEU A  13
ILE A  62
ALA A  77
PHE A  48
 None
 0.92A 5m0oC-2l2fA:
undetectable		 5m0oC-2l2fA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2l2f CYANOVIRIN-N HOMOLOG
(Fusarium
graminearum) 		4 / 8 LEU A  64
ILE A  11
ALA A  21
PHE A   4
 None
 1.01A 5m0oC-2l2fA:
undetectable		 5m0oC-2l2fA:
14.67