SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2l2g IGF2R DOMAIN 11
(Monodelphis
domestica) 		5 / 12 ILE A1564
GLY A1567
GLY A1580
ALA A1590
LEU A1548
 None
 1.01A 1i9gA-2l2gA:
undetectable		 1i9gA-2l2gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2l2g IGF2R DOMAIN 11
(Monodelphis
domestica) 		4 / 8 GLY A1580
SER A1595
ILE A1626
LEU A1606
 None
 0.75A 1jg4A-2l2gA:
undetectable		 1jg4A-2l2gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2l2g IGF2R DOMAIN 11
(Monodelphis
domestica) 		5 / 12 GLY A1591
GLY A1611
ILE A1568
LEU A1606
PHE A1628
 None
 1.05A 3ihtA-2l2gA:
undetectable		 3ihtA-2l2gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2l2g IGF2R DOMAIN 11
(Monodelphis
domestica) 		5 / 12 ALA A1590
GLY A1591
SER A1592
LYS A1623
GLN A1596
 None
 1.02A 5nwuA-2l2gA:
undetectable		 5nwuA-2l2gA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2l2g IGF2R DOMAIN 11
(Monodelphis
domestica) 		4 / 9 PHE A1654
LEU A1604
SER A1526
ASP A1601
 None
 0.86A 6c2mD-2l2gA:
undetectable		 6c2mD-2l2gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2l2g IGF2R DOMAIN 11
(Monodelphis
domestica) 		4 / 7 TYR A1554
CSS A1532
TRP A1656
LEU A1660
 None
 1.27A 6cnkB-2l2gA:
undetectable
6cnkC-2l2gA:
undetectable		 6cnkB-2l2gA:
22.38
6cnkC-2l2gA:
18.06