SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		5 / 11 ILE A  16
LEU A  72
ILE A  18
PHE A 156
THR A  14
 None
 1.09A 2w9sA-2l3fA:
undetectable		 2w9sA-2l3fA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		5 / 10 ILE A  16
LEU A  72
ILE A  18
PHE A 156
THR A  14
 None
 1.17A 2w9sD-2l3fA:
undetectable		 2w9sD-2l3fA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		5 / 10 ILE A  16
LEU A  72
ILE A  18
PHE A 156
THR A  14
 None
 1.19A 2w9sF-2l3fA:
undetectable		 2w9sF-2l3fA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A  18
ASN A  39
PHE A  41
ASN A 113
ILE A  49
 None
 1.47A 6dwnB-2l3fA:
undetectable		 6dwnB-2l3fA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		5 / 10 PHE A 112
LEU A  19
ASP A  74
GLY A 114
PHE A  97
 None
 1.07A 6ebpB-2l3fA:
undetectable		 6ebpB-2l3fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		5 / 10 PHE A 112
LEU A  19
ASP A  74
GLY A 114
PHE A  97
 None
 1.05A 6ebpC-2l3fA:
undetectable		 6ebpC-2l3fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2l3f UNCHARACTERIZED
PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 LEU A 134
ASN A  68
LEU A  72
 None
 0.68A 6exiA-2l3fA:
undetectable		 6exiA-2l3fA:
19.38