SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		5 / 10 PHE A 107
PHE A  96
ALA A  43
LEU A  27
VAL A  26
 None
 1.27A 1claA-2l3gA:
undetectable		 1claA-2l3gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		5 / 11 LEU A  55
GLY A  86
GLY A  88
SER A  90
LEU A 117
 None
 1.03A 1mx1A-2l3gA:
undetectable		 1mx1A-2l3gA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		5 / 12 LEU A  55
GLY A  86
GLY A  88
SER A  90
LEU A 117
 None
 0.95A 1mx1D-2l3gA:
undetectable		 1mx1D-2l3gA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		6 / 11 LEU A  24
LEU A  58
SER A 113
LEU A 117
ASN A 118
LEU A  54
 None
 1.42A 2ceoA-2l3gA:
undetectable		 2ceoA-2l3gA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		5 / 10 LEU A  24
LEU A  58
SER A 113
LEU A 117
ASN A 118
 None
 1.35A 2ceoB-2l3gA:
undetectable		 2ceoB-2l3gA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		5 / 10 LEU A  24
LEU A  58
LEU A 117
ASN A 118
LEU A  54
 None
 1.16A 2riwA-2l3gA:
undetectable
2riwB-2l3gA:
undetectable		 2riwA-2l3gA:
15.96
2riwB-2l3gA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		5 / 10 LEU A  24
LEU A  58
LEU A 117
ASN A 118
LEU A  54
 None
 1.08A 2xn6A-2l3gA:
undetectable
2xn6B-2l3gA:
undetectable		 2xn6A-2l3gA:
17.72
2xn6B-2l3gA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7
(Homo
sapiens) 		6 / 10 LEU A  24
LEU A  58
SER A 113
LEU A 117
ASN A 118
LEU A  54
 None
 1.14A 2xn7A-2l3gA:
undetectable
2xn7B-2l3gA:
undetectable		 2xn7A-2l3gA:
15.63
2xn7B-2l3gA:
12.70