SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2l3s AUTOINHIBITED CRK
PROTEIN
(Gallus
gallus) 		5 / 12 GLY A 278
LEU A 294
LEU A 231
HIS A 291
LEU A 259
 None
 0.99A 1zgyA-2l3sA:
undetectable		 1zgyA-2l3sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 2l3s AUTOINHIBITED CRK
PROTEIN
(Gallus
gallus) 		5 / 11 GLY A 285
VAL A 267
PHE A 289
GLY A 278
LYS A 246
 None
 1.00A 5yjsA-2l3sA:
undetectable		 5yjsA-2l3sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2l3s AUTOINHIBITED CRK
PROTEIN
(Gallus
gallus) 		4 / 8 ILE A 270
VAL A 267
ALA A 241
TYR A 240
 None
 0.86A 6cduD-2l3sA:
undetectable
6cduE-2l3sA:
undetectable		 6cduD-2l3sA:
20.06
6cduE-2l3sA:
20.06