SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 2l3t TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  80
VAL A  88
ILE A  87
ILE A  56
ILE A  44
 None
 0.97A 1fapA-2l3tA:
undetectable		 1fapA-2l3tA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2l3t TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 4 THR A 102
LEU A  98
VAL A  95
LEU A  91
 None
 0.81A 1mz9D-2l3tA:
undetectable		 1mz9D-2l3tA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2l3t TRANSCRIPTION
ELONGATION FACTOR
SPT6
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  30
TYR A   9
PHE A  11
ILE A  44
 None
 1.26A 4jx1E-2l3tA:
undetectable		 4jx1E-2l3tA:
17.58