SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2l3y INTERLEUKIN-6
(Mus
musculus) 		5 / 12 LEU A  33
LEU A 103
LEU A 180
LEU A 176
ILE A 129
 None
 0.96A 1mx1D-2l3yA:
undetectable		 1mx1D-2l3yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2l3y INTERLEUKIN-6
(Mus
musculus) 		5 / 12 LEU A  96
SER A  94
SER A 101
TYR A 102
LEU A 103
 None
 1.20A 3bxoA-2l3yA:
undetectable		 3bxoA-2l3yA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 2l3y INTERLEUKIN-6
(Mus
musculus) 		5 / 9 HIS A  36
LEU A  38
THR A 125
LEU A 103
LEU A 176
 None
 1.43A 3q1eB-2l3yA:
undetectable
3q1eD-2l3yA:
undetectable		 3q1eB-2l3yA:
23.23
3q1eD-2l3yA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2l3y INTERLEUKIN-6
(Mus
musculus) 		3 / 3 ALA A  63
ASN A  66
LEU A  67
 None
 0.45A 5i1nC-2l3yA:
undetectable		 5i1nC-2l3yA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2l3y INTERLEUKIN-6
(Mus
musculus) 		3 / 3 ALA A  63
ASN A  66
LEU A  67
 None
 0.47A 5i1pD-2l3yA:
undetectable		 5i1pD-2l3yA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2l3y INTERLEUKIN-6
(Mus
musculus) 		4 / 6 SER A 175
ASP A  60
GLN A 170
GLU A  64
 None
 1.29A 6djzA-2l3yA:
undetectable		 6djzA-2l3yA:
23.38