SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		3 / 3 ASP A  98
LEU A  92
LEU A  94
 None
 0.70A 1ikeA-2l4cA:
undetectable		 1ikeA-2l4cA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		3 / 3 ASP A  98
LEU A  92
LEU A  94
 None
 0.59A 1np1B-2l4cA:
undetectable		 1np1B-2l4cA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		4 / 8 LEU A  50
GLY A  78
ILE A  76
LEU A 107
 None
 0.75A 2o4nB-2l4cA:
undetectable		 2o4nB-2l4cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		5 / 11 SER A 108
ILE A 111
VAL A  35
PHE A  62
VAL A  60
 None
 1.32A 3rf4A-2l4cA:
undetectable
3rf4C-2l4cA:
undetectable		 3rf4A-2l4cA:
23.08
3rf4C-2l4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		5 / 11 SER A 108
ILE A 111
VAL A  35
PHE A  62
VAL A  60
 None
 1.35A 3rf4A-2l4cA:
undetectable
3rf4B-2l4cA:
undetectable		 3rf4A-2l4cA:
23.08
3rf4B-2l4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		3 / 3 ARG A 109
GLU A 112
PHE A  57
 None
 0.99A 4kszA-2l4cA:
undetectable		 4kszA-2l4cA:
11.58