SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A  41
ASP A  50
ASN A 184
 None
 1.17A 2bm9A-2l4oA:
undetectable		 2bm9A-2l4oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 LEU A 121
THR A 122
ILE A 144
HIS A 145
 None
 1.37A 2jfaB-2l4oA:
undetectable		 2jfaB-2l4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLU A  55
ALA A  44
PRO A  70
ALA A  73
 None
 0.75A 2zgwA-2l4oA:
undetectable		 2zgwA-2l4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLU A  55
ALA A  44
PRO A  70
ALA A  73
 None
 0.80A 2zgwB-2l4oA:
undetectable		 2zgwB-2l4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A 163
LEU A  43
GLU A 143
ILE A  52
LEU A  56
 None
 1.32A 3jw3B-2l4oA:
undetectable		 3jw3B-2l4oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A 143
GLU A 186
ASN A 184
 None
 0.80A 3lp9B-2l4oA:
undetectable
3lp9D-2l4oA:
undetectable		 3lp9B-2l4oA:
20.17
3lp9D-2l4oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 TRP A  83
ASN A 133
TYR A 139
LEU A 170
 None
 1.43A 4f8yA-2l4oA:
undetectable
4f8yB-2l4oA:
undetectable		 4f8yA-2l4oA:
25.00
4f8yB-2l4oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TYR A 139
LEU A 170
TRP A  83
ASN A 133
 None
 1.40A 4f8yC-2l4oA:
undetectable
4f8yD-2l4oA:
undetectable		 4f8yC-2l4oA:
25.00
4f8yD-2l4oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ILE A 168
VAL A 180
PRO A 182
 None
 0.73A 5uunA-2l4oA:
undetectable		 5uunA-2l4oA:
21.43