SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 111
PHE A  17
VAL A  21
ILE A  50
LEU A  85
 None
 0.97A 1fe2A-2l4qA:
undetectable		 1fe2A-2l4qA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 111
VAL A  21
ILE A  50
LEU A  85
 None
 0.86A 1igxA-2l4qA:
undetectable		 1igxA-2l4qA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		4 / 8 THR A  59
ALA A  61
LEU A  63
VAL A  28
 None
 0.94A 1sn5C-2l4qA:
undetectable		 1sn5C-2l4qA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 105
VAL A  77
ILE A  95
LEU A  58
VAL A  28
 None
 1.46A 3oxzA-2l4qA:
undetectable		 3oxzA-2l4qA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		4 / 8 THR A  59
ALA A  61
LEU A  63
VAL A  28
 None
 0.81A 4iizB-2l4qA:
undetectable		 4iizB-2l4qA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		4 / 8 THR A  59
ALA A  61
LEU A  63
VAL A  28
 None
 0.83A 4ik7B-2l4qA:
undetectable		 4ik7B-2l4qA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 108
LEU A  29
LEU A 104
GLU A  49
LEU A  47
 None
 1.18A 4wg0F-2l4qA:
undetectable
4wg0G-2l4qA:
undetectable
4wg0H-2l4qA:
undetectable		 4wg0F-2l4qA:
7.96
4wg0G-2l4qA:
7.96
4wg0H-2l4qA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  12
ILE A  10
VAL A  30
ALA A  61
 None
 0.60A 5ospA-2l4qA:
undetectable		 5ospA-2l4qA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2l4q THIOREDOXIN
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  12
ILE A  10
VAL A  30
ALA A  61
 None
 0.59A 5osrA-2l4qA:
undetectable		 5osrA-2l4qA:
14.62