SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG
(Methanosarcina
acetivorans) 		5 / 12 THR A  82
ILE A  92
GLY A  91
GLY A  71
ILE A  74
 None
 1.04A 1nv8B-2l52A:
undetectable		 1nv8B-2l52A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG
(Methanosarcina
acetivorans) 		5 / 12 THR A  82
ILE A  92
GLY A  91
GLY A  71
ILE A  74
 None
 1.04A 1sg9B-2l52A:
undetectable		 1sg9B-2l52A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG
(Methanosarcina
acetivorans) 		4 / 8 PRO A  94
ALA A  12
LEU A  14
ALA A  17
 None
 0.89A 2vcvF-2l52A:
undetectable		 2vcvF-2l52A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG
(Methanosarcina
acetivorans) 		4 / 6 PRO A  94
ALA A  12
LEU A  14
ALA A  17
 None
 0.86A 2vcvK-2l52A:
undetectable		 2vcvK-2l52A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2l52 METHANOSARCINA
ACETIVORANS SAMP1
HOMOLOG
(Methanosarcina
acetivorans) 		5 / 12 VAL A   8
LEU A  68
GLY A  91
ILE A  65
LEU A  14
 None
 1.30A 4o5fA-2l52A:
undetectable
4o5fB-2l52A:
undetectable		 4o5fA-2l52A:
19.57
4o5fB-2l52A:
19.57