SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  38
ALA A  41
GLU A  92
LEU A 181
VAL A 180
 None
 1.06A 2bxeB-2l5aA:
undetectable		 2bxeB-2l5aA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  38
ALA A  41
GLU A  92
SER A 183
VAL A 180
 None
 1.00A 2bxeB-2l5aA:
undetectable		 2bxeB-2l5aA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 213
ASP A 208
ALA A 212
ILE A 102
 None
 1.09A 2qhfA-2l5aA:
undetectable		 2qhfA-2l5aA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 208
ALA A  31
THR A 205
THR A 203
 None
 1.43A 4z4fA-2l5aA:
undetectable		 4z4fA-2l5aA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 208
ALA A  31
THR A 205
THR A 203
 None
 1.44A 4z4gA-2l5aA:
undetectable		 4z4gA-2l5aA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  89
THR A 219
PRO A  80
ARG A  81
 None
 1.34A 6ew0B-2l5aA:
undetectable		 6ew0B-2l5aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  89
THR A 219
PRO A  80
ARG A  81
 None
 1.34A 6ew0D-2l5aA:
undetectable		 6ew0D-2l5aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  89
THR A 219
PRO A  80
ARG A  81
 None
 1.34A 6ew0H-2l5aA:
undetectable		 6ew0H-2l5aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  89
THR A 219
PRO A  80
ARG A  81
 None
 1.33A 6ew0I-2l5aA:
undetectable		 6ew0I-2l5aA:
15.32