SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		5 / 10 ILE A 175
LEU A 159
GLY A  57
PHE A 190
ALA A 141
 None
 1.49A 1ju6C-2l5pA:
undetectable		 1ju6C-2l5pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		5 / 11 GLY A 112
GLN A 113
THR A 108
ILE A 133
GLN A  40
 None
 1.33A 2dr2A-2l5pA:
undetectable		 2dr2A-2l5pA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		4 / 7 VAL A 143
SER A 158
LEU A 105
THR A  76
 None
 1.08A 2f78A-2l5pA:
undetectable		 2f78A-2l5pA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		4 / 7 VAL A 143
SER A 158
LEU A 105
THR A  76
 None
 1.11A 2f78B-2l5pA:
undetectable		 2f78B-2l5pA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		3 / 3 GLN A 181
THR A 178
LEU A 160
 None
 0.75A 3ondA-2l5pA:
undetectable		 3ondA-2l5pA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		3 / 3 GLN A 181
THR A 178
LEU A 160
 None
 0.73A 3ondB-2l5pA:
undetectable		 3ondB-2l5pA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		5 / 12 HIS A 168
ILE A 175
LEU A 159
GLY A  57
PHE A 190
 None
 1.35A 4foxE-2l5pA:
undetectable		 4foxE-2l5pA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2l5p LIPOCALIN 12
(Rattus
norvegicus) 		4 / 7 ILE A 175
THR A 167
ILE A 166
PHE A 190
 None
 0.81A 5fukA-2l5pA:
undetectable
5fukB-2l5pA:
undetectable		 5fukA-2l5pA:
21.14
5fukB-2l5pA:
21.14