SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PKV_A_RBFA100_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	2l69	ROSSMANN 2X3 FOLD PROTEIN (synthetic construct)	5 / 11	SER A 9 LEU A 15 THR A 14 ILE A 53 ILE A 81	None	1.12A	1pkvA-2l69A: undetectable 1pkvB-2l69A: undetectable	1pkvA-2l69A: 22.39 1pkvB-2l69A: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PKV_B_RBFB101_1 (RIBOFLAVIN SYNTHASE ALPHA CHAIN)	2l69	ROSSMANN 2X3 FOLD PROTEIN (synthetic construct)	5 / 11	ILE A 81 SER A 9 LEU A 15 THR A 14 ILE A 53	None	1.14A	1pkvA-2l69A: undetectable 1pkvB-2l69A: undetectable	1pkvA-2l69A: 22.39 1pkvB-2l69A: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H4D_A_BBIA403_1 (NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL)	2l69	ROSSMANN 2X3 FOLD PROTEIN (synthetic construct)	4 / 6	ARG A 105 GLU A 103 GLU A 123 VAL A 124	None	1.40A	5h4dA-2l69A: 2.5	5h4dA-2l69A: 16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JWA_A_ACTA612_0 (NADH DEHYDROGENASE, PUTATIVE)	2l69	ROSSMANN 2X3 FOLD PROTEIN (synthetic construct)	3 / 3	LYS A 61 ASP A 60 ARG A 89	None	0.98A	5jwaA-2l69A: undetectable 5jwaH-2l69A: undetectable	5jwaA-2l69A: 11.71 5jwaH-2l69A: 11.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PKV_A_RBFA100_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","2l69","ROSSMANN 2X3 FOLD PROTEIN","synthetic construct",5,"SER A   9;LEU A  15;THR A  14;ILE A  53;ILE A  81","None","1.12A","1pkvA-2l69A:undetectable;1pkvB-2l69A:undetectable","1pkvA-2l69A:22.39;1pkvB-2l69A:22.39"],["1PKV_B_RBFB101_1","RIBOFLAVIN SYNTHASE ALPHA CHAIN;RIBOFLAVIN SYNTHASE ALPHA CHAIN","2l69","ROSSMANN 2X3 FOLD PROTEIN","synthetic construct",5,"ILE A  81;SER A   9;LEU A  15;THR A  14;ILE A  53","None","1.14A","1pkvA-2l69A:undetectable;1pkvB-2l69A:undetectable","1pkvA-2l69A:22.39;1pkvB-2l69A:22.39"],["5H4D_A_BBIA403_1","NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL","2l69","ROSSMANN 2X3 FOLD PROTEIN","synthetic construct",4,"ARG A 105;GLU A 103;GLU A 123;VAL A 124","None","1.40A","5h4dA-2l69A:2.5","5h4dA-2l69A:16.73"],["5JWA_A_ACTA612_0","NADH DEHYDROGENASE, PUTATIVE","2l69","ROSSMANN 2X3 FOLD PROTEIN","synthetic construct",3,"LYS A  61;ASP A  60;ARG A  89","None","0.98A","5jwaA-2l69A:undetectable;5jwaH-2l69A:undetectable","5jwaA-2l69A:11.71;5jwaH-2l69A:11.71"]]