SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		5 / 12 ALA A  53
LEU A  19
THR A  64
ILE A  63
LEU A  12
 None
 1.15A 1ddsA-2l6aA:
undetectable		 1ddsA-2l6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		4 / 4 LEU A  19
PRO A  55
LEU A  27
ARG A  84
 None
 1.35A 1hrkB-2l6aA:
undetectable		 1hrkB-2l6aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		4 / 4 LEU A  19
PRO A  55
LEU A  27
ARG A  84
 None
 1.33A 2hrcB-2l6aA:
undetectable		 2hrcB-2l6aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		4 / 4 LEU A  19
PRO A  55
LEU A  27
ARG A  84
 None
 1.44A 2pnjB-2l6aA:
undetectable		 2pnjB-2l6aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		5 / 12 ALA A  53
LEU A  19
THR A  64
ILE A  63
LEU A  12
 None
 1.14A 4ej1B-2l6aA:
undetectable		 4ej1B-2l6aA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		5 / 12 ALA A  53
LEU A  19
THR A  64
ILE A  63
LEU A  12
 None
 1.09A 4qleA-2l6aA:
undetectable		 4qleA-2l6aA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		5 / 12 ALA A  53
LEU A  19
THR A  64
ILE A  63
LEU A  12
 None
 1.14A 4x5gA-2l6aA:
undetectable		 4x5gA-2l6aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12
(Homo
sapiens) 		5 / 12 ALA A  53
LEU A  19
THR A  64
ILE A  63
LEU A  12
 None
 1.13A 4x5hA-2l6aA:
undetectable		 4x5hA-2l6aA:
18.40