SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 12 LEU A  51
LEU A  54
ASN A  17
VAL A  25
ALA A  24
 None
 1.14A 1sa1C-2l6fA:
undetectable
1sa1D-2l6fA:
undetectable		 1sa1C-2l6fA:
17.16
1sa1D-2l6fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 11 LEU A  21
ALA A  76
VAL A  58
LEU A  65
THR A  19
 None
 1.43A 3jwqB-2l6fA:
3.1
3jwqC-2l6fA:
undetectable		 3jwqB-2l6fA:
18.07
3jwqC-2l6fA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 11 LEU A  87
HIS A 115
LEU A 117
ALA A 113
LEU A 170
 None
 1.01A 4p65E-2l6fA:
undetectable
4p65F-2l6fA:
undetectable
4p65J-2l6fA:
undetectable
4p65L-2l6fA:
undetectable		 4p65E-2l6fA:
6.58
4p65F-2l6fA:
6.90
4p65J-2l6fA:
6.90
4p65L-2l6fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 12 SER A  68
ASN A  11
VAL A  14
VAL A 127
LEU A 125
 None
 0.84A 5kocA-2l6fA:
undetectable		 5kocA-2l6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 12 SER A  68
ASN A  11
VAL A  14
VAL A 127
LEU A 125
 None
 0.84A 5kocB-2l6fA:
undetectable		 5kocB-2l6fA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN
(Gallus
gallus;
unidentified) 		4 / 6 LEU A  80
LEU A 124
LEU A  65
GLU A  60
 None
 0.95A 5tudD-2l6fA:
8.3		 5tudD-2l6fA:
19.31