SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 11 LEU A  87
HIS A 115
LEU A 117
ALA A 113
LEU A 170
 None
 1.11A 4p65E-2l6gA:
undetectable
4p65F-2l6gA:
undetectable
4p65J-2l6gA:
undetectable
4p65L-2l6gA:
undetectable		 4p65E-2l6gA:
8.12
4p65F-2l6gA:
7.95
4p65J-2l6gA:
7.95
4p65L-2l6gA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 12 GLU A  60
LEU A  65
ILE A 128
VAL A  18
ASP A  59
 None
 1.24A 5vlmG-2l6gA:
undetectable		 5vlmG-2l6gA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 12 VAL A  47
LEU A 111
ALA A 114
LEU A 170
GLY A  20
 None
 0.98A 6b0cD-2l6gA:
undetectable		 6b0cD-2l6gA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN
(Gallus
gallus;
unidentified) 		5 / 12 VAL A  58
ILE A  73
ASN A 123
VAL A 127
ILE A 128
 None
 1.47A 6gsdA-2l6gA:
undetectable		 6gsdA-2l6gA:
17.14