SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2l6p PHAC1, PHAC2 AND
PHAD GENES
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  85
ARG A  94
THR A  84
 None
 0.87A 1df7A-2l6pA:
undetectable		 1df7A-2l6pA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2l6p PHAC1, PHAC2 AND
PHAD GENES
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  88
LEU A  91
ALA A  92
LEU A  28
ILE A   8
 None
 1.22A 1g50A-2l6pA:
undetectable		 1g50A-2l6pA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2l6p PHAC1, PHAC2 AND
PHAD GENES
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  31
TRP A  99
LYS A  15
 None
 1.24A 4k7aA-2l6pA:
undetectable		 4k7aA-2l6pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2l6p PHAC1, PHAC2 AND
PHAD GENES
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  92
THR A  93
GLU A  90
GLY A  22
ASP A  86
 None
 1.19A 5lf3V-2l6pA:
undetectable
5lf3W-2l6pA:
undetectable		 5lf3V-2l6pA:
17.98
5lf3W-2l6pA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 2l6p PHAC1, PHAC2 AND
PHAD GENES
(Pseudomonas
aeruginosa) 		5 / 11 ALA A  92
THR A  93
GLU A  90
GLY A  22
ASP A  86
 None
 1.11A 5lf7V-2l6pA:
undetectable
5lf7W-2l6pA:
undetectable		 5lf7V-2l6pA:
17.98
5lf7W-2l6pA:
19.51