SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 GLN A 156
THR A  18
SER A  22
GLN A 275
 None
 1.47A 1eiiA-2l7bA:
undetectable		 1eiiA-2l7bA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 1.24A 1fbmA-2l7bA:
undetectable		 1fbmA-2l7bA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 4 ALA A 257
ARG A 158
GLN A 258
GLU A  96
 None
 1.47A 1lqtB-2l7bA:
undetectable		 1lqtB-2l7bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 4 ALA A 257
ARG A 158
GLN A 258
GLU A  96
 None
 1.47A 1lquB-2l7bA:
undetectable		 1lquB-2l7bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 4 LEU A  37
VAL A 111
CYH A 112
ALA A 193
 None
 1.25A 1mz9E-2l7bA:
undetectable		 1mz9E-2l7bA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 5 LEU A  82
VAL A 161
TYR A 162
THR A  83
 None
 1.37A 1nw3A-2l7bA:
1.3		 1nw3A-2l7bA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 8 LYS A 242
ASP A 110
ARG A 103
ALA A 102
 None
 1.40A 2rk8A-2l7bA:
undetectable		 2rk8A-2l7bA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 PRO A 267
THR A  83
PRO A  84
VAL A  85
 None
 1.05A 2v2gC-2l7bA:
undetectable
2v2gD-2l7bA:
undetectable		 2v2gC-2l7bA:
21.85
2v2gD-2l7bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 8 PRO A 267
THR A  83
PRO A  84
VAL A  85
 None
 0.98A 2v41C-2l7bA:
undetectable
2v41D-2l7bA:
undetectable		 2v41C-2l7bA:
21.85
2v41D-2l7bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 7 PRO A 267
THR A  83
PRO A  84
VAL A  85
 None
 1.01A 2v41E-2l7bA:
undetectable
2v41F-2l7bA:
undetectable		 2v41E-2l7bA:
21.85
2v41F-2l7bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 TYR A  36
LEU A  14
ARG A  38
 None
 0.81A 3sufB-2l7bA:
undetectable		 3sufB-2l7bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 GLU A  59
GLN A  55
TRP A 210
LEU A 214
 None
 1.45A 4qzuC-2l7bA:
undetectable		 4qzuC-2l7bA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		5 / 10 ASP A 153
ALA A 100
SER A 263
LEU A 261
ALA A 259
 None
 1.10A 4zbrA-2l7bA:
3.0		 4zbrA-2l7bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 ASP A 151
ARG A 274
ARG A 260
 None
 0.82A 5eajB-2l7bA:
undetectable		 5eajB-2l7bA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 LEU A 159
LEU A  71
ARG A  15
 None
 0.54A 5hnzB-2l7bA:
undetectable		 5hnzB-2l7bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 5 ASP A 271
ARG A 264
ARG A 260
LEU A  30
 None
 1.21A 5tuiB-2l7bA:
undetectable		 5tuiB-2l7bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 5 ASP A 271
ARG A 264
ARG A 260
LEU A  71
 None
 1.48A 5tuiB-2l7bA:
undetectable		 5tuiB-2l7bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2l7b APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 ARG A 142
LYS A 146
ARG A 274
 None
 1.06A 6c06D-2l7bA:
1.9		 6c06D-2l7bA:
undetectable