SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2l7n TALIN-1
(Mus
musculus) 		5 / 12 LEU A1105
LEU A1106
ALA A1103
VAL A1192
ILE A1119
 None
 1.07A 1s9pC-2l7nA:
undetectable		 1s9pC-2l7nA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2l7n TALIN-1
(Mus
musculus) 		5 / 12 CYH A1087
LEU A1091
ALA A1134
ALA A1140
LYS A1077
 None
 1.10A 1sa1A-2l7nA:
undetectable
1sa1B-2l7nA:
undetectable		 1sa1A-2l7nA:
18.75
1sa1B-2l7nA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2l7n TALIN-1
(Mus
musculus) 		5 / 12 CYH A1087
LEU A1091
ALA A1134
ALA A1140
LYS A1077
 None
 1.09A 1sa1C-2l7nA:
undetectable
1sa1D-2l7nA:
undetectable		 1sa1C-2l7nA:
18.75
1sa1D-2l7nA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2l7n TALIN-1
(Mus
musculus) 		5 / 9 VAL A1192
VAL A1057
LEU A1196
LEU A1131
VAL A1124
 None
 1.21A 6czmB-2l7nA:
undetectable
6czmC-2l7nA:
undetectable		 6czmB-2l7nA:
21.86
6czmC-2l7nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2l7n TALIN-1
(Mus
musculus) 		4 / 8 ALA A1121
LEU A1105
ALA A1169
LYS A1170
 None
 0.72A 6mdqA-2l7nA:
2.6		 6mdqA-2l7nA:
21.92