SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_E_ACTE3005_0 (BETA-CARBONIC ANHYDRASE)	2l80	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (Homo sapiens)	4 / 7	CYH A 24 HIS A 57 GLY A 54 GLY A 53	ZN A 124 (-2.2A) ZN A 124 (-3.1A) ZN A 124 ( 4.1A) None	0.94A	1ekjE-2l80A: undetectable 1ekjF-2l80A: undetectable	1ekjE-2l80A: 20.00 1ekjF-2l80A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_A_ACTA505_0 (RNA POLYMERASE 3D-POL)	2l80	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (Homo sapiens)	3 / 3	CYH A 44 ASN A 55 LYS A 46	ZN A 124 (-2.2A) None None	1.20A	4k50A-2l80A: undetectable	4k50A-2l80A: 14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1K_D_LOCD502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	2l80	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (Homo sapiens)	4 / 4	ASN A 36 SER A 85 ALA A 70 VAL A 71	None	1.01A	4x1kC-2l80A: undetectable	4x1kC-2l80A: 13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NM5_B_LOCB502_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	2l80	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (Homo sapiens)	4 / 4	ASN A 36 SER A 85 ALA A 70 VAL A 71	None	1.06A	5nm5A-2l80A: undetectable	5nm5A-2l80A: 13.01

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_E_ACTE3005_0","BETA-CARBONIC ANHYDRASE","2l80","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13","Homo sapiens",4,"CYH A  24;HIS A  57;GLY A  54;GLY A  53"," ZN A 124 (-2.2A); ZN A 124 (-3.1A); ZN A 124 ( 4.1A);None","0.94A","1ekjE-2l80A:undetectable;1ekjF-2l80A:undetectable","1ekjE-2l80A:20.00;1ekjF-2l80A:20.00"],["4K50_A_ACTA505_0","RNA POLYMERASE 3D-POL","2l80","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13","Homo sapiens",3,"CYH A  44;ASN A  55;LYS A  46"," ZN A 124 (-2.2A);None;None","1.20A","4k50A-2l80A:undetectable","4k50A-2l80A:14.91"],["4X1K_D_LOCD502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","2l80","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13","Homo sapiens",4,"ASN A  36;SER A  85;ALA A  70;VAL A  71","None","1.01A","4x1kC-2l80A:undetectable","4x1kC-2l80A:13.01"],["5NM5_B_LOCB502_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","2l80","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13","Homo sapiens",4,"ASN A  36;SER A  85;ALA A  70;VAL A  71","None","1.06A","5nm5A-2l80A:undetectable","5nm5A-2l80A:13.01"]]