SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2l81 ENHANCER OF
FILAMENTATION 1
(Homo
sapiens) 		5 / 11 HIS A 109
LEU A  40
VAL A  65
GLU A  69
ALA A 148
 None
 1.05A 2yy8A-2l81A:
undetectable
2yy8B-2l81A:
undetectable		 2yy8A-2l81A:
21.78
2yy8B-2l81A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2l81 ENHANCER OF
FILAMENTATION 1
(Homo
sapiens) 		4 / 8 ILE A 162
LEU A 158
LEU A  26
LEU A 102
 None
 0.76A 4zvcA-2l81A:
7.4
4zvcB-2l81A:
7.3		 4zvcA-2l81A:
20.12
4zvcB-2l81A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2l81 ENHANCER OF
FILAMENTATION 1
(Homo
sapiens) 		4 / 8 LEU A 102
ILE A 162
LEU A 158
LEU A  26
 None
 0.78A 4zvcA-2l81A:
7.4
4zvcB-2l81A:
7.3		 4zvcA-2l81A:
20.12
4zvcB-2l81A:
20.12