SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 8 VAL A 104
TRP A  72
PHE A  95
GLU A 101
 None
 1.49A 1om5A-2l82A:
undetectable
1om5B-2l82A:
undetectable		 1om5A-2l82A:
17.54
1om5B-2l82A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 7 VAL A 104
TRP A  72
PHE A  95
GLU A 101
 None
 1.49A 3svpA-2l82A:
1.7
3svpB-2l82A:
undetectable		 3svpA-2l82A:
17.49
3svpB-2l82A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 8 ARG A  40
GLU A  43
GLU A  47
LYS A  50
 None
 0.94A 4bqfB-2l82A:
2.7		 4bqfB-2l82A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 7 TRP A  72
PHE A  95
GLU A 101
VAL A 104
 None
 1.47A 4imwA-2l82A:
1.7
4imwB-2l82A:
undetectable		 4imwA-2l82A:
17.49
4imwB-2l82A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 7 TRP A  72
PHE A  95
GLU A 101
VAL A 104
 None
 1.48A 4kciA-2l82A:
undetectable
4kciB-2l82A:
undetectable		 4kciA-2l82A:
17.49
4kciB-2l82A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 6 VAL A 104
TRP A  72
PHE A  95
GLU A 101
 None
 1.47A 4v3wA-2l82A:
0.0
4v3wB-2l82A:
0.0		 4v3wA-2l82A:
17.49
4v3wB-2l82A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 7 TRP A  72
PHE A  95
GLU A 101
VAL A 104
 None
 1.46A 5ad4A-2l82A:
undetectable
5ad4B-2l82A:
undetectable		 5ad4A-2l82A:
17.49
5ad4B-2l82A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 6 ARG A 147
PHE A 107
GLU A 140
VAL A 135
 None
 1.27A 5h4dA-2l82A:
2.8		 5h4dA-2l82A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 6 TRP A  72
PHE A  95
GLU A 101
VAL A 104
 None
 1.49A 5unvA-2l82A:
undetectable
5unvB-2l82A:
undetectable		 5unvA-2l82A:
17.49
5unvB-2l82A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2l82 DESIGNED PROTEIN
OR32
(synthetic
construct) 		4 / 7 TRP A  72
PHE A  95
GLU A 101
VAL A 104
 None
 1.50A 5uo5A-2l82A:
undetectable
5uo5B-2l82A:
undetectable		 5uo5A-2l82A:
17.41
5uo5B-2l82A:
17.41