SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2l8a ENDOGLUCANASE
(Bacillus
subtilis) 		3 / 3 GLN A 466
TYR A 358
ARG A 359
 None
 0.96A 1gtbA-2l8aA:
undetectable		 1gtbA-2l8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2l8a ENDOGLUCANASE
(Bacillus
subtilis) 		3 / 3 TYR A 358
TYR A 470
GLU A 435
 None
 0.81A 3pfgA-2l8aA:
undetectable		 3pfgA-2l8aA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2l8a ENDOGLUCANASE
(Bacillus
subtilis) 		5 / 9 LEU A 374
ILE A 354
ILE A 493
PHE A 438
VAL A 389
 None
 1.36A 3tmzA-2l8aA:
undetectable		 3tmzA-2l8aA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2l8a ENDOGLUCANASE
(Bacillus
subtilis) 		3 / 3 TYR A 393
ASP A 469
ASP A 431
 None
 0.83A 4a6eA-2l8aA:
undetectable		 4a6eA-2l8aA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2l8a ENDOGLUCANASE
(Bacillus
subtilis) 		4 / 8 ILE A 354
ALA A 391
VAL A 389
VAL A 356
 None
 0.72A 5ecnD-2l8aA:
undetectable		 5ecnD-2l8aA:
14.31