SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2l8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		5 / 12 ILE A 466
THR A 518
ARG A 527
LEU A 519
LEU A 433
 None
 1.21A 1eiiA-2l8bA:
undetectable		 1eiiA-2l8bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		3 / 3 ASP A 479
THR A 504
GLU A 485
 None
 0.72A 2zifB-2l8bA:
1.7		 2zifB-2l8bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		5 / 9 GLN A 492
ASP A 523
VAL A 532
VAL A 505
GLN A 464
 None
 1.37A 3fi0D-2l8bA:
undetectable		 3fi0D-2l8bA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		5 / 9 GLN A 492
ASP A 523
VAL A 532
VAL A 505
GLN A 464
 None
 1.44A 3fi0F-2l8bA:
undetectable		 3fi0F-2l8bA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		5 / 9 GLN A 492
ASP A 523
VAL A 532
VAL A 505
GLN A 464
 None
 1.40A 3fi0J-2l8bA:
undetectable		 3fi0J-2l8bA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 5 GLN A 531
THR A 504
THR A 535
LEU A 426
 None
 1.08A 4lvcB-2l8bA:
undetectable		 4lvcB-2l8bA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 5 GLN A 531
THR A 504
THR A 535
LEU A 426
 None
 1.13A 6aphA-2l8bA:
undetectable		 6aphA-2l8bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 5 GLN A 531
VAL A 532
PRO A 431
THR A 535
 None
 1.37A 6cduA-2l8bA:
undetectable
6cduB-2l8bA:
undetectable		 6cduA-2l8bA:
19.14
6cduB-2l8bA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 5 GLN A 531
VAL A 532
PRO A 431
THR A 535
 None
 1.41A 6cduI-2l8bA:
undetectable
6cduJ-2l8bA:
undetectable		 6cduI-2l8bA:
19.14
6cduJ-2l8bA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		5 / 8 LEU A 426
THR A 535
VAL A 449
VAL A 436
LEU A 452
 None
 1.48A 6czmD-2l8bA:
undetectable
6czmF-2l8bA:
undetectable		 6czmD-2l8bA:
19.89
6czmF-2l8bA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 4 GLN A 531
THR A 504
THR A 535
LEU A 426
 None
 1.13A 6f3mA-2l8bA:
undetectable		 6f3mA-2l8bA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 4 GLN A 531
THR A 504
THR A 535
LEU A 426
 None
 1.13A 6f3mC-2l8bA:
undetectable		 6f3mC-2l8bA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2l8b PROTEIN TRAI
(Escherichia
coli) 		4 / 5 GLN A 531
THR A 504
THR A 535
LEU A 426
 None
 1.11A 6gbnB-2l8bA:
undetectable		 6gbnB-2l8bA:
21.53