SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2la3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2la3 UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A  42
PHE A  46
LEU A  12
LEU A 150
LEU A  51
 None
 1.41A 1p33C-2la3A:
undetectable		 1p33C-2la3A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2la3 UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 8 SER A  42
PHE A  46
LEU A  12
LEU A 146
LEU A 150
 None
 1.34A 2bfpC-2la3A:
undetectable		 2bfpC-2la3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2la3 UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A  51
PHE A 152
LEU A 150
LEU A 140
VAL A 142
 None
 1.26A 2po5B-2la3A:
undetectable		 2po5B-2la3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2la3 UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 9 ILE A  47
ARG A  44
ALA A  39
VAL A  43
 None
 1.07A 2vufB-2la3A:
undetectable		 2vufB-2la3A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2la3 UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TYR A  91
LEU A  79
ARG A  85
 None
 0.74A 3sufB-2la3A:
undetectable		 3sufB-2la3A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2la3 UNCHARACTERIZED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ASP A  64
SER A  42
TYR A 121
VAL A 142
 None
 0.98A 6giqL-2la3A:
undetectable
6giqP-2la3A:
undetectable
6giqT-2la3A:
undetectable		 6giqL-2la3A:
17.66
6giqP-2la3A:
24.36
6giqT-2la3A:
14.88