SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2la4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UT5_B_LOCB502_1 (TUBULIN BETA CHAIN)	2la4	NUCLEAR AND CYTOPLASMIC POLYADENYLATED RNA-BINDING PROTEIN PUB1 (Saccharomyces cerevisiae)	5 / 12	ALA A 395 THR A 341 ALA A 343 ILE A 345 ILE A 381	None	1.01A	3ut5B-2la4A: undetectable	3ut5B-2la4A: 11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_B_LOCB504_2 (TUBULIN BETA CHAIN)	2la4	NUCLEAR AND CYTOPLASMIC POLYADENYLATED RNA-BINDING PROTEIN PUB1 (Saccharomyces cerevisiae)	5 / 12	ALA A 395 THR A 341 ALA A 343 ILE A 345 ILE A 381	None	1.02A	5xiwB-2la4A: undetectable	5xiwB-2la4A: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_2 (TUBULIN BETA CHAIN)	2la4	NUCLEAR AND CYTOPLASMIC POLYADENYLATED RNA-BINDING PROTEIN PUB1 (Saccharomyces cerevisiae)	5 / 12	ALA A 395 THR A 341 ALA A 343 ILE A 345 ILE A 381	None	0.87A	5xiwD-2la4A: undetectable	5xiwD-2la4A: 20.79