SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		5 / 10 LEU A 259
TYR A 280
LEU A 326
LEU A 334
VAL A 337
 None
 1.09A 1cqpA-2laeA:
undetectable
1cqpB-2laeA:
undetectable		 1cqpA-2laeA:
22.66
1cqpB-2laeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		5 / 12 SER A 314
LEU A 255
GLY A 308
SER A 269
VAL A 278
 None
 1.13A 1fduA-2laeA:
undetectable		 1fduA-2laeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		5 / 12 SER A 314
LEU A 255
GLY A 308
SER A 269
VAL A 266
 None
 1.15A 1fduC-2laeA:
undetectable		 1fduC-2laeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		4 / 7 LYS A 304
LEU A 305
GLN A 306
LEU A 259
 None
 1.11A 1v55C-2laeA:
undetectable
1v55J-2laeA:
undetectable		 1v55C-2laeA:
18.55
1v55J-2laeA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		4 / 7 LYS A 304
LEU A 305
GLN A 306
LEU A 259
 None
 1.04A 2einC-2laeA:
undetectable
2einJ-2laeA:
undetectable		 2einC-2laeA:
18.55
2einJ-2laeA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		5 / 11 PRO A 296
LEU A 334
TYR A 280
TYR A 303
LEU A 326
 None
 1.16A 5hbmA-2laeA:
undetectable		 5hbmA-2laeA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		3 / 3 THR A 327
SER A 329
ASP A 295
 None
 0.84A 5kvaA-2laeA:
undetectable		 5kvaA-2laeA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2lae LIPOPROTEIN 34
(Escherichia
coli) 		3 / 3 THR A 327
SER A 329
ASP A 295
 None
 0.85A 5kvaB-2laeA:
undetectable		 5kvaB-2laeA:
20.69