SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2lak AHSA1-LIKE PROTEIN
RHE_CH02687
(Rhizobium
etli) 		6 / 12 GLY A 132
HIS A 129
ALA A 138
ARG A  13
ALA A  15
HIS A  16
 None
 1.00A 2gluB-2lakA:
undetectable		 2gluB-2lakA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2lak AHSA1-LIKE PROTEIN
RHE_CH02687
(Rhizobium
etli) 		4 / 5 LEU A  17
LEU A 134
MET A  28
TRP A 127
 None
 1.41A 4do3A-2lakA:
undetectable		 4do3A-2lakA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2lak AHSA1-LIKE PROTEIN
RHE_CH02687
(Rhizobium
etli) 		5 / 11 ALA A  18
LEU A  17
GLU A 136
LEU A 134
LEU A  27
 None
 0.92A 4wg0C-2lakA:
undetectable
4wg0D-2lakA:
undetectable
4wg0E-2lakA:
undetectable		 4wg0C-2lakA:
8.16
4wg0D-2lakA:
8.16
4wg0E-2lakA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2lak AHSA1-LIKE PROTEIN
RHE_CH02687
(Rhizobium
etli) 		5 / 11 ALA A  18
LEU A  17
GLU A 136
LEU A 134
LEU A  27
 None
 0.93A 4wg0E-2lakA:
undetectable
4wg0F-2lakA:
undetectable
4wg0G-2lakA:
undetectable		 4wg0E-2lakA:
8.16
4wg0F-2lakA:
8.16
4wg0G-2lakA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2lak AHSA1-LIKE PROTEIN
RHE_CH02687
(Rhizobium
etli) 		3 / 3 LEU A  27
LEU A 134
ARG A  74
 None
 0.56A 5hnzB-2lakA:
undetectable		 5hnzB-2lakA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2lak AHSA1-LIKE PROTEIN
RHE_CH02687
(Rhizobium
etli) 		4 / 8 PRO A 147
GLY A 144
PRO A 143
ASP A 146
 None
 1.14A 5kf8A-2lakA:
undetectable		 5kf8A-2lakA:
21.04