SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 9 VAL A 114
GLY A 115
ALA A 158
PHE A 169
ILE A  95
 None
 1.10A 1cetA-2laoA:
undetectable		 1cetA-2laoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 11 ILE A  68
ALA A  66
VAL A  43
LEU A 217
ALA A 213
 None
 1.06A 1n4hA-2laoA:
undetectable		 1n4hA-2laoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		6 / 12 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.32A 2h77A-2laoA:
undetectable		 2h77A-2laoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		6 / 12 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.37A 2h79A-2laoA:
undetectable		 2h79A-2laoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 12 ALA A  82
LEU A 206
VAL A   6
ILE A   8
MET A  41
 None
 0.97A 3adxB-2laoA:
undetectable		 3adxB-2laoA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		6 / 12 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.39A 3gwsX-2laoA:
undetectable		 3gwsX-2laoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		4 / 4 LEU A  87
ILE A   8
GLY A 196
PHE A 210
 None
 1.13A 4dc3A-2laoA:
undetectable		 4dc3A-2laoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		6 / 12 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.42A 4lnwA-2laoA:
undetectable		 4lnwA-2laoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		6 / 12 ALA A 209
MET A  37
ALA A  66
LEU A 199
LEU A  87
ILE A  68
 None
 1.41A 4lnxA-2laoA:
undetectable		 4lnxA-2laoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A 206
VAL A   6
ILE A   8
MET A  41
 None
 0.82A 4oj4A-2laoA:
undetectable		 4oj4A-2laoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A 155
ALA A 158
LEU A 159
GLY A 168
LEU A 170
 None
 1.05A 4xi3C-2laoA:
undetectable		 4xi3C-2laoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		4 / 5 ARG A  77
PHE A  52
LEU A  55
LEU A  87
 None
 1.31A 5veuH-2laoA:
undetectable		 5veuH-2laoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN
(Salmonella
enterica) 		5 / 12 GLN A 122
ILE A 146
TYR A 147
LEU A 150
ILE A 102
 None
 1.21A 5y2tB-2laoA:
undetectable		 5y2tB-2laoA:
undetectable