SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2lav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		4 / 5 GLU A  73
LYS A 179
ASP A 177
THR A 224
 None
 1.46A 1rr8C-2lavA:
0.0		 1rr8C-2lavA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		3 / 3 GLN A  95
HIS A 171
ARG A 203
 None
 1.04A 1zlqA-2lavA:
undetectable		 1zlqA-2lavA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		3 / 3 MET A  56
VAL A  25
GLU A  60
 None
 0.85A 2x9gA-2lavA:
undetectable		 2x9gA-2lavA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		5 / 7 PRO A 296
LEU A 155
LEU A 324
ILE A 299
MET A 286
 None
 1.47A 3u5jA-2lavA:
undetectable		 3u5jA-2lavA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		5 / 9 PRO A 296
LEU A 155
LEU A 324
ILE A 299
MET A 286
 None
 1.48A 4c66A-2lavA:
undetectable		 4c66A-2lavA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		3 / 3 ASN A 182
LEU A 165
PHE A 227
 None
 0.82A 4dajB-2lavA:
3.0		 4dajB-2lavA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		5 / 9 VAL A  69
VAL A  70
ILE A  43
GLY A  40
ALA A  66
 None
 1.04A 4fwdA-2lavA:
undetectable		 4fwdA-2lavA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		4 / 8 VAL A  69
ALA A  54
GLY A  40
GLY A  63
 None
 0.89A 5e26C-2lavA:
undetectable
5e26D-2lavA:
undetectable		 5e26C-2lavA:
22.57
5e26D-2lavA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		5 / 12 PHE A 227
LEU A 247
SER A 229
GLY A 242
GLY A 176
 None
 1.26A 5o4yD-2lavA:
undetectable
5o4yE-2lavA:
undetectable		 5o4yD-2lavA:
3.62
5o4yE-2lavA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens) 		3 / 3 ASP A 222
ASP A 197
ASN A 346
 None
 0.74A 6gngB-2lavA:
undetectable		 6gngB-2lavA:
20.13